Effect of gastrointestinal hormone infusions of lower oesophageal competence of rhesus monkeys.
Br J Surg, 1978/7;65(7):499-504.
Moosa AR, Hall AW, Hughes RG, Moraldi A, Moosa DE, Skinner DB
PMID: 96906
Impact factor: 11.122
Abstract
The lower oesophageal high pressure zone (HPZ) was studied in 5 non-refluxing and 3 refluxing Rhesus monkeys. The changes in HPZ and reflux status in response to infusion of various doses of secretin, cholecystokinin and glucagon were measured in all animals, and, in the 5 non-refluxing monkeys, after oesophagogastrectomy with replacement of the lower oesophagus by a stomach tube. All three hormones consistently produced a transient decrease in the HPZ pressure. The only change in response following oesophagagastrectomy and gastric tube replacement was a significant delay in the response to each hormone. Neither hormone infusion nor operation altered gastro-oesophageal reflux status. It appears that lower oesophageal competence in primates is more dependent on the presence of narrow, muscular, intra-abdominal tube than on a specialized segment of the lower oesophagus.
MeSH terms
Animals; Cholecystokinin; Esophagogastric Junction; Esophagus; Gastrectomy; Gastroesophageal Reflux; Glucagon; Haplorhini; Macaca mulatta; Male; Pressure; Secretin; Time Factors
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