The relationship between beta-blockade, hyporeninaemic and hypotensive effect of two beta-blocking agents.
Postgrad Med J, 1976;52 Suppl 4:102-8.
Amery A, De Plaen JF, Fagard R, Linjen P, Reybrouck T
PMID: 9626
Impact factor: 4.973
Abstract
In two consecutive series of hypertensive patients the hypotensive effect, the hyporeninaemic effect and the blockade of cardiac beta-receptors was studied using weekly increasing doses of propranolol or atenolol. With both beta-blockers, cardiac blockade and hypotensive effect increased in a parallel fashion when the dosage was increased suggesting that the hypotensive effect is related to cardiac beta-blockade. On the other hand lack of parallelism between the hypotensive effect and the hyporeninaemic effect suggests that the hypotensive effect was not related to a major extent to the hyporeninaemic effect of the drugs in the dosage range studied here.
MeSH terms
Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure; Heart Rate; Humans; Middle Aged; Propanolamines; Propranolol; Renin
More resources
EndNote: Download