[Biosynthesis of penicillin upon periodic culturing of Penicillium chrysogenum with an exponentially increasing glucose supply].
Prikl Biokhim Mikrobiol, 1979/3-1979/4;15(2):233-9.
PMID: 95828
Abstract
Penicillium chrysogenum was cultivated under controlled conditions and at constant specific growth rates regulated by glucose supply. The rate of penicillin synthesis (units/mg dry weight.hr) and pattern of time changes of the synthesizing capacity of the culture depended on the specific growth rate (hr-1). The arrest of penicillin synthesis was induced by the inherent changes of the culture rather than by external factors, e.g. use of substrates, changed limitation, accumulation of inhibitory metabolites, etc.
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