Heterogeneity, immunological comparison and concentration profiles of alpha-fetoproteins derived from late-gestational and early postnatal mouse tissue.
J Reprod Immunol, 1979/7;1(2):75-87.
PMID: 95198
Impact factor: 3.993
Abstract
Four distinct alpha-fetoprotein (AFP) species were separated by ion-exchange chromatography of the approximately 70 000 dalton fraction of an extract of late-gestation fetal mice. Although chromatographicaly heterogeneous, antigenic differences among the AFP species resolved were not detected using classical double-diffusion methods. Analysis of the AFP contribution to total body saline-extractable protein of fetal and neonatal mice revealed an abrupt decrease in the fetal AFP contribution to total body saline-extractable protein commencing after the 18th day of gestation.
MeSH terms
Absorption; Animals; Animals, Newborn; Antigen-Antibody Complex; Chromatography, Gel; Chromatography, Ion Exchange; Epitopes; Female; Immune Sera; Immunodiffusion; Mice; Molecular Weight; Pregnancy; Proteins; alpha-Fetoproteins
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