Alien H-2 allospecificities in murine chemically-induced tumors.
Immunol Commun, 1979;8(5-6):555-62.
PMID: 94037
Abstract
Sera from C3H/HeHa mice immunized with syngeneic methylcholanthrene-induced sarcoma react with allogeneic thymus, lymphoma and leukemia cells. The presence on leukemia and lymphoma cells of H-2 specificities expressed on normal cells of other H-2 haplotypes from the one in which the tumor originates is described. It was observed that the reaction of antisera to H-2 specificities with lymphoma cells was blocked by anti-MCA sarcoma sera. The cross-reactivity between MC sarcomas, thymus, leukemia and lymphoma cells is considered to be due to antibodies against these "alien" allospecificities.
MeSH terms
Animals; Antibodies, Neoplasm; Binding, Competitive; Cross Reactions; Cytotoxicity, Immunologic; Epitopes; Female; H-2 Antigens; Immune Sera; Leukemia, Experimental; Lymphoma, Non-Hodgkin; Male; Methylcholanthrene; Mice; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Rabbits; Sarcoma, Experimental
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