Are histamine H2-receptor depressions of neuronal activity in tissue cultures from rat hypothalamus mediated through cyclic adenosine monophosphate?
Neurosci Lett, 1979/9;14(1):49-53.
PMID: 93718
Impact factor: 3.197
Abstract
Iontophoretic application of histamine H2-agonists depressed spontaneous firing of tuberal hypothalamic neurons in tissue culture. Perfusion with inhibitors of cyclic nucleotide phosphodiesterase increased the strength of these depressions, which persisted during perfusion with Ca2+-free medium. These results support a role of cyclic AMP as a mediator of histamine H2-elicited depressions of neuronal activity.
MeSH terms
1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Culture Techniques; Cyclic AMP; Hypothalamus; Rats; Receptors, Histamine; Receptors, Histamine H2
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