[Short-term effects of gamma-globulins on sleep organization in epileptic patients (author's transl)].
Rev Electroencephalogr Neurophysiol Clin, 1979/7-1979/9;9(3):266-76.
Laffont F, Cathala HP, Pechadre JC, Esnault S, Gilbert A, Eygonnet JP
PMID: 93297
Abstract
A study of the effect of gamma-globulins on sleep was conducted in 8 patients aged 1 to 35 years with epilepsy not responding to any of the conventional treatments. Two polygraphic recordings were carried out during the 4th and 5th nights following a placebo injection and then an injection of gamma-globulin 16 Merieux (1 ml/kg). The short-term effects of the gamma-globulins were : --reduction in percentage of paroxysms, --an acceleration in the electroencephalographic tracings of the different stages of sleep and those of the waking period, --a statistically significant increase in the percentage of paradoxical sleep, though the general organization of sleep remained unchanged.
MeSH terms
Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Male; Sleep; Sleep, REM; gamma-Globulins
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