Regulation of the kidney xanthine dehydrogenase by glutaminase.
Arch Int Physiol Biochim, 1979/5;87(2):223-7.
Affonso OR, Santos LJ, Mitidieri E
PMID: 92920
Abstract
The steady-state concentrations of glutamine, glutamate and ammonia in the kidney cells might regulate the rate of renal xanthine dehydrogenase activity. Both glutamate and glutamine were found to be effective inhibitors of the renal xanthine dehydrogenase activity in vivo. The inhibition by glutamate depends essentially on the glutaminase inhibition.
MeSH terms
Animals; Cytosol; Glutamates; Glutaminase; Glutamine; Ketone Oxidoreductases; Kidney; Kinetics; Male; Rats; Xanthine Dehydrogenase
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