Synthesis and pharmacological properties of 1,2,3,4-tetrahydroisoquinoline derivatives.
Acta Pol Pharm, 1996/1-1996/2;53(1):25-9.
Brzezińska E[1]
Affiliations
PMID: 8960281
Impact factor: 0.555
Abstract
Selected 2-isopropyl-4,6,8-trihydroxy-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated as beta-adrenoreceptor agents. These orciprenaline derivatives were found as week, partial agonists of beta-adrenoreceptors. Some of them showed good binding properties.
MeSH terms
Adrenergic beta-Agonists; Aldehydes; Animals; Binding Sites; Bronchodilator Agents; Cerebral Cortex; Drug Design; Female; Guinea Pigs; Isoproterenol; Isoquinolines; Magnetic Resonance Spectroscopy; Male; Membrane Proteins; Rats; Rats, Wistar; Receptors, Adrenergic, beta-2; Reference Standards; Structure-Activity Relationship; Tetrahydroisoquinolines; Trachea
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