[Role of alpha 1-antitrypsin and alpha-2 macroglobulin in hepatopathies].

Minerva Med, 1979/2/18;70(8):605-10.

Triolo L, Mian G, Magris D, Novello E, D'Agnolo B

PMID: 86175

Impact factor: 5.58

Abstract
Two pictures of alpha 1-antitrypsin deficiency, one associated with alpha 2-macroglobulin deficiency and one isolated case of the latter deficiency have been observed in three patients suffering from cirrhosis of the liver and/or hepatoma. On the basis of these cases, the literature on the subject is reviewed. The unusually high incidence of such anti-enzymatic deficiencies (three cases in the first eleven patients studied) in severe liver pathology, calls for a reassessment of such research and suggests that these tests should be carried out on a routine basis in cases of cryptogenetic cirrhosis and probably for long-term prognosis in cases of viral hepatitis.
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