Transformation of normal bone-marrow cells by a leukaemic cell line associated with a presumptive new human virus.
Lancet, 1978/11/11;2(8098):1016-9.
Karpas A, Wreghitt TG, Nagington J
PMID: 82033
Impact factor: 202.731
Abstract
Intracytoplasmic leukovirus-like bodies were found in the cells and culture medium of a T-cell lymphoblast line established from a leukaemic patient. When the cells were lethally irradiated and added to normal bone-marrow cells the latter were transformed into continuous replication and produced the same types of virus-like particle.
MeSH terms
Adult; Bone Marrow; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Female; Golgi Apparatus; Humans; In Vitro Techniques; Inclusion Bodies, Viral; Leukemia, Monocytic, Acute; Male; Microscopy, Electron; Middle Aged; Radiation Dosage; Retroviridae; Staining and Labeling; T-Lymphocytes
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