Immune response of prostatic cancer patients to cytomegalovirus-infected and -transformed human cells.
Cancer, 1978/10;42(4):1766-71.
Laychock AM, Geder L, Sanford EJ, Rapp F
PMID: 81717
Impact factor: 6.921
Abstract
The indirect immunofluorescent test was used to determine the prevalence of humoral immunity to cytomegalovirus (CMV)-induced antigens in prostatic cancer patients as compared to age-matched controls. Significantly more prostatic cancer patients demonstrated high CMV-antibody titers than did the benign prostatic hyperplasia and nonurogenital cancer groups; however, no significant difference in reactivity was found between paients with prostatic cancer and transitional cell carcinoma of the urinary bladder. When screened against CMV-transformed human cell lines, the reactivity of the sera followed the rate of expression of CMV-related antigens of cell lines used in these tests.
MeSH terms
Aged; Antibodies, Neoplasm; Antibodies, Viral; Antigens, Neoplasm; Antigens, Viral; Carcinoma, Transitional Cell; Cell Line; Cell Transformation, Neoplastic; Cytomegalovirus; Humans; In Vitro Techniques; Male; Middle Aged; Neoplasms; Prostatic Hyperplasia; Prostatic Neoplasms; Urinary Bladder Neoplasms
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