Independent analysis of T helper and T killer cell function in young and old NZB mice.
J Immunol, 1978/9;121(3):897-902.
Falkoff RM, Scavulli JF, Dutton RW
PMID: 80432
Impact factor: 5.426
Abstract
With age, NZB mice lose their ability to develop a cytotoxic response after alloimmunization in vitro. This decline is shown to coincide with a diminution of T-helper cell activity as assessed by proliferation in mixed lymphocyte culture or in response to PHA. When cytotoxic T cell precursors are activated with the polyclonal activator Con A, there is no reduction in the number of cytotoxic effector T cells that develop. No autoreactive cytotoxic cells are seen in Con A-activated cultures. These findings are related to previous work on cell-mediated immunity in NZB and B/W mice.
MeSH terms
Aging; Animals; Concanavalin A; Cytotoxicity, Immunologic; Epitopes; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Mice, Inbred NZB; T-Lymphocytes
More resources
EndNote: Download