Radioiodinated fatty acids for myocardial imagine: effects on chain length.
J Nucl Med, 1981/7;22(7):613-8.
Otto CA, Brown LE, Wieland DM, Beierwaltes WH
PMID: 7252566
Impact factor: 11.082
Abstract
Terminally iodinated long-chain fatty acids have been used experimentally and clinically as myocardial imaging agents. Six omega-iodo fatty acids (I(CH2)n CO2H, where n = 10, 12, 15, 18, 21, 26) have been synthesized and tested in rats. Myocardial extraction values and heart-to-blood ratios are affected by chain length. Extraction is shown to be highest for n = 18 and 21, as are heart-to-blood ratios at 5 min. The cellular fate of the fatty acid changes form that of beta -oxidation for n less than or equal to 15 to predominantly triglyceride storage for n = 18 and 21, as shown by analysis of rat heart homogenates by thin layer chromatography at two time intervals.
MeSH terms
Animals; Chromatography, Thin Layer; Fatty Acids; Female; Heart; Iodine Radioisotopes; Myocardium; Radionuclide Imaging; Rats; Structure-Activity Relationship; Time Factors; Tissue Distribution
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