Secretin-induced histamine release in duodenal-ulcer patients.
Lancet, 1977/4/30;1(8018):928-9.
Baenkler HW, Mitznegg P, Domschke S, Wünsch E, Subramanian N, Domschke W, Bötticher R, Sprügel W, Demling L
PMID: 67387
Impact factor: 202.731
Abstract
Because a majority of duodenal-ulcer patients responded locally to intradermal secretin, skin samples from 7 patients with duodenal ulceration and 6 patients with goitre or cholelithiasis were incubated with "tris" buffer alone and with tris buffer containing 20 C.U./ml synthetic secretin or 100 microng/ml compound 48/80. Skin from duodenal-ulcer patients released significantly more histamine than did that of controls (p less 0-01). Histological examination of skin samples from these patients showed that the number of histamine-containing mast-cells averaged 5-7 per field and dropped to 1-2 per field after incubation with secretin. It is concluded that in a certain type of duodenal ulceration intradermal secretin releases histamine from mast-cells and thus induces a local anaphylactic reaction. This might prove suitable for preclinical ulcer diagnosis and/or for detection of patients at risk of acquiring that disease.
MeSH terms
Adult; Anaphylaxis; Culture Techniques; Duodenal Ulcer; Female; Histamine Release; Humans; Hypersensitivity, Immediate; Injections, Intradermal; Male; Mast Cells; Middle Aged; Risk; Secretin; Skin; Skin Manifestations; p-Methoxy-N-methylphenethylamine
More resources
EndNote: Download