The effect of endotoxin on the mast cell c'AMP system.
Ann Allergy, 1977/2;38(2):104-6.
Glauser FL, Palmer J, Cecconi S, Schoolcraft W, Wells I, Novey H, Egan P, Smeltzer D
PMID: 65929
Abstract
To determine whether the endotoxin induced release of histamine is mediated via the mast cell c'AMP system, hamster mast cells were isolated and incubated (prior to endotoxin-serum stimulates (ET-S) with disodium cromoglycate, isoproterenol and aminophylline. All drugs caused significant inhibition of the ET-S histamine release. The authors conclude that ET-S utilizes the c'AMP system to release histamine.
MeSH terms
Aminophylline; Animals; Atropine; Cricetinae; Cromolyn Sodium; Cyclic AMP; Endotoxins; Histamine Release; In Vitro Techniques; Isoproterenol; Mast Cells; Phentolamine
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