Pharmacokinetic behaviour of bleomycin-cobalt-57 with special regard to intraarterial perfusion of the maxillo-facial region.
J Maxillofac Surg, 1976/12;4(4):226-31.
PMID: 64577
Abstract
Bleomycin was traced by the isotope Cobalt-57. By using this radioactive substance the pharmacokinetic behaviour of the drug was examined. It was given either intravenously or intra-arterially or directly into the tumor in patients suffering from epidermoid carcinoma in the maxillo-facial region. The differences in the pharmacokinetic data are delineated. Practically, the intra-arterial route of administration is the best one because of the high adherence rate of the drug to the perfused tissue.
MeSH terms
Bleomycin; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Cobalt Radioisotopes; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Kinetics; Radionuclide Imaging
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