Cross reactivity of human beta2-microglobulin with human granulocyte colony-stimulating activity.
J Immunol, 1976/8;117(2):416-8.
Price GB, McCulloch EA, Till JE
PMID: 59777
Impact factor: 5.426
Abstract
Effects of antisera to human beta2-microglobulin (beta2 m) on factors able to stimulate colony formation in culture by human granulopoietic progenitor cells were investigated. The colony-stimulating activity (CSA) present in media conditioned by cultures of human peripheral leukocytes was suppressed by treatment with anti-beta2m. This inhibition was not due to a direct effect on the granulopietic progenitor cells; controls to test for cytotoxicity and for noncytotoxic inhibition of the progenitor cells by anti-beta2m yielded negative results. These experiments provide evidence for a relationship between human CSA and beta-microglobulin, and suggest a possible analogy between molceules involved in the in vitro regulation of granulopoiesis and products of the major histocompatibility gene complex.
MeSH terms
Animals; Beta-Globulins; Cell Division; Colony-Stimulating Factors; Cross Reactions; Glycoproteins; Goats; Granulocytes; Hematopoiesis; Histocompatibility Antigens; Humans; Immune Sera; Leukocytes; beta 2-Microglobulin
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