A new look at type I immediate hypersensitivity immune reactions.
Ann Allergy, 1976/5;36(5):337-41.
PMID: 59557
Abstract
The pathogenesis of type I disorders, particularly allergic asthma and urticaria, requires a critical review in the light of recent findings which indicate a second pathway for the release of granulocyte mediators. The isolation of enzyme activity of some of these released mediator establishes a direct link between the immunological system and bradykinin, as well as a system of self modulation of kinin activity. These findings open the door for a broader understanding of the asthmatic process and lay the foundation for integrating extrinsic and intrinsic asthma.
MeSH terms
Asthma; Basophils; Bradykinin; Complement C5; Eosinophils; Granulocytes; Histamine Release; Humans; Hypersensitivity, Immediate; Immunity, Cellular; Mast Cells
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