Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.
Nature, 1975/11/13;258(5531):121-5.
PMID: 52847
Impact factor: 69.504
Abstract
A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens-carcinogens. The test gives a very sensitive and rapid method for detecting chromosome mutagenicity of chemical agents and provides a powerful new method for detecting environmental mutagens.
MeSH terms
Bromodeoxyuridine; Carcinogens; Cell Line; Chromatids; Chromosome Aberrations; Chromosomes; Crossing Over, Genetic; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Mutagens; Radiation Genetics; Staining and Labeling; X-Rays
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