Suppressor cells in the embryonic thymus mediate allograft tolerance.
Adv Exp Med Biol, 1976;66:571-6.
PMID: 4964
Impact factor: 3.65
Abstract
Thymus cells from non-immunized young chickens suppress the allograft rejection in lightly irradiated syngeneic or allogeneic recipients and mediate longlasting skingraft survival in a significant proportion of recipients across a strong histocompatibility difference. Suppressive activity of this kind is already found in the embryonic thymus and is therefore believed to mediate also self tolerance and neonatal allograft tolerance.
MeSH terms
Age Factors; Animals; B-Lymphocytes; Chick Embryo; Chickens; Erythrocytes; Graft Rejection; Graft vs Host Reaction; Immune Tolerance; Immunosuppression Therapy; Lymphocytes; Skin Transplantation; Spleen; T-Lymphocytes; Transplantation, Homologous
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