Doxantrazole, an antiallergic agent orally effective in man.
Lancet, 1975/5/24;1(7917):1169-70.
Batchelor JF, Follenfant MJ, Garland LG, Gorvin JH, Green AF, Hodson HF, Hughes DT, Tateson JE
PMID: 48779
Impact factor: 202.731
Abstract
In-vivo studies have demonstrated antiallergic properties in doxantrazole when given orally to rats. These properties were confirmed in work with in-vitro preparations. No significant animal toxicity has been detected. 200 mg. given by mouth inhibited the immediate-type asthmatic response in volunteer patients challenged with specific antigen.
MeSH terms
Administration, Oral; Animals; Asthma; Drug Evaluation; Drug Evaluation, Preclinical; Histamine Release; Humans; In Vitro Techniques; Rats; Tetrazoles; Thioxanthenes; Xanthones
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