Extracellular pH selectively modulates recovery from sodium inactivation in frog myelinated nerve.
Biophys J, 1979/11;28(2):363-8.
PMID: 45411
Impact factor: 3.699
Abstract
The Hodgkin-Huxley kinetic parameters, alpha h and beta h, which govern the rate of recovery from and development of sodium channel inactivation, respectively, have been measured as a function of membrane potential and external pH using a three-pulse protocol. alpha h but not beta h is substantially accelerated by reducing external pH from 7.4 to 6.4. The alpha h vs. voltage curve appears to be selectively shifted in the depolarizing direction by approximately 12 mV for this pH change, giving an apparent, h infinity curve shift of approximately 6 mV in the same direction (less inactivation).
MeSH terms
Animals; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Myelin Sheath; Rana catesbeiana; Sciatic Nerve; Sodium
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