Effect of levamisole on the auto-antibody formation in nude mice.
Int Arch Allergy Appl Immunol, 1979;59(2):222-6.
Ogita T, Hayakawa T, Horiuchi Y, Mizushima Y
PMID: 447410
Abstract
The effects of levamisole on the formation of antibody to double-stranded DNA (ds-DNA), an auto-antibody, and to some thymus-dependent antigens were studied in nude (nu/nu) mice. The antibody titre to ds-DNA in nu/nu mice treated with levamisole was lower than that in control animals. The number of Thy-1-antigen-positive (Thy-1+) cells in the spleen from nu/nu mice treated with levamisole was higher than that from non-treated animals. It is suggested that the Thy-1+ cells were induced by levamisole in nu/nu mice and these cells suppressed the formation of antibody to ds-DNA, whereas the formation of antibody to a DNP-conjugate (OVA) and SRBC, thymus-dependent antigens, was not evoked in nu/nu mice after the treatment with levamisole.
MeSH terms
Animals; Antibody Formation; Antigens; Autoantibodies; DNA; Dinitrobenzenes; Erythrocytes; Female; Immunoglobulin E; Immunoglobulin M; Levamisole; Lymphocytes; Mice; Mice, Nude; Ovalbumin; Sheep
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