Age-related decrease of ultraviolet light-induced DNA repair synthesis in human peripheral leukocytes.
Cancer Res, 1979/7;39(7 Pt 1):2792-5.
Lambert B, Ringborg U, Skoog L
PMID: 445484
Impact factor: 13.312
Abstract
The capacity for ultraviolet light-induced DNA repair synthesis, studied in peripheral leukocytes from 58 healthy subjects 13 to 94 years old, was found to vary greatly between individuals. A negative, statistically significant correlation was obtained between age and this synthesis, indicating a decrease in repair capacity with age. An age-related decrease in DNA repair may increase the susceptibility of cells to agents causing DNA damage, i.e. carcinogens and certain cytostatic drugs.
MeSH terms
Adolescent; Adult; Aged; Aging; DNA; DNA Repair; Humans; Leukocytes; Lymphocytes; Middle Aged; Ultraviolet Rays
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