Pharmacological properties of axonal sodium channels in the cockroach Periplaneta americana L. II. Slowing of sodium current turn-off by Condylactis toxin.
J Exp Biol, 1979/12;83:49-58.
PMID: 43882
Impact factor: 3.308
Abstract
Condylactis toxin induces a prolonged falling phase in action potentials recorded from giant axons of the cockroach Periplaneta americana L. A distinct plateau potential can be recorded in the presence of Condylactis toxin at concentrations of 0.5 mg/ml and above. In cockroach axons, voltage-clamp experiments show that Condylactis toxin acts primarily by slowing the sodium current turn-off without affecting either the time-course of the sodium conductance increase or the peak amplitude of the transient sodium current.
MeSH terms
Action Potentials; Animals; Axons; Cnidarian Venoms; Cockroaches; Electric Conductivity; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Periplaneta
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