Nitrosomethylurea (MNU): a powerful carcinogen for mouse skin. A study utilising the tetrazolium test (TZT) and topical skin applications.
Virchows Arch B Cell Pathol Incl Mol Pathol, 1979/6/29;30(3):363-5.
PMID: 43013
Abstract
Nitrosomethylurea (MNU) was tested with the tetrazolium test for skin carcinogens with positive results. 39 hairless mice were painted once a week with a 1% solution of MNU in acetone. After 18 weeks all the animals bore tumours and 90% had skin carcinomas. Hence, the strong carcinogenic potency of MNU was confirmed, and the validity of the tetrazolium test was given further support.
MeSH terms
Animals; Carcinogens; Methylnitrosourea; Mice; Mice, Nude; Nitrosourea Compounds; Skin Neoplasms; Tetrazolium Salts
More resources
EndNote: Download