Effect of metiamide on acid secretion from isolated kitten fundic mucosa.
Can J Physiol Pharmacol, 1975/12;53(6):1141-6.
Tepperman BL, Schofield B, Tepperman FS
PMID: 4205
Impact factor: 2.245
Abstract
Isolated kitten fundic mucosa demonstrates low rates of spontaneous acid secretion in vitro when bathed in Krebs-Henseleit solution, and responds consistently to histamine, pentagastrin, and acetylcholine placed in the bath. High rates of spontaneous secretion or secretion in response to histamine and pentagastrin were significantly inhibited by addition of metiamide (5 X 10(-3) M); but mucosa stimulated by constant addition of acetylcholine chloride (10(-4) M) was not inhibited by metiamide at the same concentration.
MeSH terms
Acetylcholine; Animals; Cats; Female; Gastric Juice; Gastric Mucosa; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Male; Metiamide; Pentagastrin; Stimulation, Chemical; Thiourea; Time Factors
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