Sequence of the full-length immunoglobulin kappa-chain of mouse myeloma MPC 11.
Biochem J, 1978/5/01;171(2):337-47.
PMID: 418775
Impact factor: 3.766
Abstract
MPC 11 mouse myeloma cells synthesize two immunoglobulin kappa light chains, coded by two separate genes. One of these Kappa-chains has no variable region and is degraded intracellularly. The other is a full-length kappa-chain contaning both variable and constant regions: this chain is secreted, both by itself and combined with heavy chains in molecules of immunoglobulin G. This paper reports the amino acid sequence of the myeloma MPC 11 full-length kappa-chain. The chain is unusual in having 12 extra residues at its N-terminus when its sequence is aligned with those of other mouse kappa-chains; no other anomalies were found in its sequence.
MeSH terms
Amino Acid Sequence; Animals; Immunoglobulin G; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Immunoglobulin kappa-Chains; Mice; Multiple Myeloma
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download