Metabolic effects of clofibrate in insulin-dependent ketosis-prone diabetic man.
Metabolism, 1978/4;27(4):461-8.
Schade DS, Eaton RP, George S, Conway M, Kaminsky N, Sivinski J
PMID: 416322
Impact factor: 13.934
Abstract
This study examined the effects of clofibrate therapy on basal plasma substrate and hormone concentrations in ketosis-prone insulin-dependent diabetic man. A double-blind crossover design was utilized during a 3-mo period in which clofibrate treatment (1 g b.i.d.) was compared to that of a lactose placebo (1 g b.i.d.). Our results demonstrate that clofibrate treatment resulted in a significant reduction in the concentration of plasma glucose, ketone bodies, free fatty acids, triglyceride, and cholesterol in diabetic man. These beneficial effects were observed without demonstrable changes in circulating concentrations of insulin and glucagon. These observations suggest that in ketosis-prone diabetic man, clofibrate therapy may provide an adjunct to exogenous insulin administration.
MeSH terms
Adult; Aged; Blood Glucose; Clinical Trials as Topic; Clofibrate; Diabetes Mellitus; Diabetic Ketoacidosis; Fatty Acids, Nonesterified; Glucagon; Humans; Insulin; Ketone Bodies; Middle Aged; Triglycerides
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