Studies on the mobilization of iron from ferritin by isolated rat liver mitochondria.
Biochim Biophys Acta, 1979/12/03;588(2):256-71.
PMID: 41594
Abstract
Rat liver mitochondria and rat liver mitoplasts mobilize iron from ferritin by a mechanism which depends on a respiratory substrate (preferentially succinate), a small molecular weight electron mediator (FMN, phenazine methosulphate or methylene blue) and (near) anaerobic conditions. The release process under optimized conditions (approx. 50 mumol/1 FMN, 1 mmol/l succinate, 0.35 mmol/1 Fe(III) (as ferritin iron), 37 degrees C and pH 7.40) amounts to 0.9--1.2 nmol iron/mg protein per min. The results suggest that ferritin might function as an intermediate in the cytosolic transport of iron to the mitochondria.
MeSH terms
Animals; Antimycin A; Carboxylic Acids; Coloring Agents; Cyanides; Ferritins; Hydrogen-Ion Concentration; Iron; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxygen; Phenanthrolines; Rats; Rotenone; Subcellular Fractions; Temperature
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