[On the narco-hypnotic of o-chloro 2-phenyl ethyl allophanate (S. C. S. 100) in animal (author's transl)].
Anesth Analg (Paris), 1979/1-1979/2;36(1-2):1-5.
Foussard-Blanpin O, Uchida-Ernouf G
PMID: 39471
Abstract
Oral administration of o-chloro 2-phenyl éthyl allophanate (S. C. S. 100) to male and pregnant, or not, female mice, to male and female rats, to male guinea-pigs and rabbits induces, according to tested doses and animal species, a reduction of motoricity, a state of sleepiness giving way to exterior solicitations, a loss of balance, a diminution of muscular tonus or a temporary loss of righting reflex going with narcosis and a reversible suppression of sensibility. The narco-hynoticaction of S. C. S. 100 qualitatively similar to that of secobarbital needs 1.5 to 3 times higher doses to appear and has a little longer latent period but without any excitation. The new synthesized molecule differs also from the barbiturate as its therapeutic index is 3 times more important which means a better maniability confirmed moreover in mouse after several repeated administrations of ED 50 doses of S. C. S. 100.
MeSH terms
Animals; Antipsychotic Agents; Female; Guinea Pigs; Hypnotics and Sedatives; Male; Mice; Motor Activity; Rabbits; Rats; Secobarbital; Sleep; Urea
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