[Mass-spectrometric analysis of 2-aminobenzophenone derivatives and their metabolites].
Bioorg Khim, 1986/5;12(5):686-94.
Golovenko NIa, Zin'kovskiĭ VG, Andronati SA, Iavorskiĭ AS
PMID: 3730010
Abstract
Mass-spectrometry analysis was carried out for 2-aminobenzophenone, its halogen derivatives and metabolites formed in the rat organism. The characteristic fragmentation patterns were outlined for the products arising on hydroxylation of the above compounds. The structural specificity in the oxidation of 2-aminobenzophenones was found to be different from that predominant in hydroxylation of phenyl (o-chlorophenyl) ring of 1,4-benzodiazepines which give on hydrolysis the respective benzophenones.
MeSH terms
Animals; Benzodiazepines; Benzophenones; Biotransformation; Chemical Phenomena; Chemistry; Male; Mass Spectrometry; Oxidation-Reduction; Rats; Rats, Inbred Strains
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