Isolation and characterization of an actinomycin D-sensitive mutant of Saccharomyces cerevisiae.
J Bacteriol, 1978/10;136(1):142-7.
Gorenstein C, Atkinson KD, Falkes EV
PMID: 361685
Impact factor: 3.476
Abstract
A single mutation in Saccharomyces cerevisiae conferred sensitivity to low concentrations of actinomycin D. Treatment with actinomycin D preferentially inhibited synthesis of rRNA's. Residual rRNA synthesized was processed normally. Total protein synthesis and inducibility of the enzyme maltase were relatively unaffected at concentrations of actinomycin D which severely inhibited rRNA synthesis.
MeSH terms
Dactinomycin; Enzyme Induction; Fungal Proteins; Genes; Mutation; RNA, Messenger; RNA, Ribosomal; Saccharomyces cerevisiae; Spheroplasts; alpha-Glucosidases
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