Group B streptococcal infections in neonates and infants. Report of 16 cases, with referrence to the fatal outcome in late-onset leucopenic cases.
S Afr Med J, 1978/7/22;54(4):154-8.
Jacobs MR, Koornhof HJ, Stein H
PMID: 358431
Impact factor: 2.162
Abstract
Sixteen cases of group B streptococcal (GBS) infections in neonates and infants aged up to 3 months were detected from November 1973 to January 1977. Three patients presented with pneumonia, 10 with meningitis and 3 with both pneumonia and meningitis. All diagnoses were confirmed by positive blood and/or cerebrospinal fluid cultures. The serotypes involved were type Ia (2 cases), type II (4 cases) and type III (10 cases). Ten patients died (62.5%). Early antibiotic treatment did not appear to affect the outcome, but low peripheral leucocyte count indicated a uniformly fatal outcome in 6 cases where leucopenia was documented, and this appeared to be associated with late-onset disease. The current status of GBS disease is presented, with particular reference to the control measures at present available and the possibility of immunotherapy and vaccination.
MeSH terms
Diagnosis, Differential; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Leukocyte Count; Leukopenia; Male; Streptococcal Infections; Streptococcus agalactiae
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