Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat.
Gastroenterol Jpn, 1978;13(3):190-6.
Moriga M, Kojima K, Aono M, Uchino H, Yajima H
PMID: 357240
Abstract
The effect of somatostatin (GH-RIH) on gastric, pancreatic and biliary secretion was examined in the anesthetized rats. Intravenous infusion of the hormone, in graded doses ranging from 1 to 16 microgram/kg/hr, produced a dose dependent inhibition of pentagastrin, 1.5 microgram/kg/hr, induced acid secretion, reaching about 54% of control level at the dose of 16 microgram/kg/hr. Somatostatin, 4, 16 and 64 microgram/kg/hr, inhibited the pancreatic juice volume stimulated by intravenous injection of secretin, 1 u/kg, as a bolus. Somatostastin, 2, 8, 32 and 128 microgram/kg/30 min, did not change the bile flow rate in control period. Somatostatin may play a physiological role in the regulation of the secretory process of the stomach and pancreas.
MeSH terms
Animals; Bile; Depression, Chemical; Female; Gastric Juice; Infusions, Parenteral; Pancreas; Pancreatic Juice; Pentagastrin; Pepsin A; Rats; Somatostatin; Stomach
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