The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets.
Pflugers Arch, 1978/3/20;373(3):237-42.
Malaisse WJ, Boschero AC, Kawazu S, Hutton JC
PMID: 355997
Impact factor: 4.458
Abstract
The effect of glucose upon the handling of K+ by islets of Langerhans removed from normal rats was investigated by measuring both the net uptake of 86Rb+ and its efflux from prelabelled islets. The inflow of K+ into islet cells is mediated, in part at least, by an ouabain-sensitive pump. Glucose fails to affect the inflow rate of K+, but it apparently decreases the permeability of islet cells plasma membrane to effuent K+. The glucose-induced change in permeability is a rapid and rapidly reversible phenomenon. Under steady-state conditions, it leads to an increase in the islet cells K+ pool and a decrease of its fractional turnover rate.
MeSH terms
Animals; Cell Membrane Permeability; Dose-Response Relationship, Drug; Female; Glucose; In Vitro Techniques; Islets of Langerhans; Ouabain; Potassium; Rats; Rubidium; Time Factors
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