Effect of demycarosylturimycin on ribosomal peptidyltransferase from Escherichia coli.
J Antibiot (Tokyo), 1978/6;31(6):610-5.
Haupt I, Fricke H, Cerná J, Rychlík I
PMID: 355215
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Abstract
The effect of demycarosylturimycin H on bacterial growth, polypeptide synthesis and peptidyltransferase was studied. The effects are compared with those of intact turimycins acylated or deacylated in 4''-position of mycarose. The removal of the acyl group in 4''-position of mycarose leads to a total loss of inhibition of acceptor substrate binding while the removal of acyl mycarose moiety changes the pattern of inhibition of polypeptide synthesis.
MeSH terms
Acyltransferases; Anti-Bacterial Agents; Drug Interactions; Erythromycin; Escherichia coli; Leucomycins; Peptide Biosynthesis; Peptidyl Transferases; Puromycin; Ribosomes
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