The effect of hycanthone and maleic hydrazide on the frequency of micronuclei in the bone-marrow erythrocytes of mice.
Mutat Res, 1978/5;57(2):187-91.
Chaubey RC, Kavi BR, Chauhan PS, Sundaram K
PMID: 351389
Impact factor: 3.151
Abstract
Male Swiss mice were assigned to 6 groups of either 3 or 4 animals each. 3 groups were given hycanthone methanesulfonate intraperitoneally, at 40, 80 or 120 mg/kg, respectively; the dose was repeated after an interval of about 24 h. At the same time 2 groups received maleic hydrazide at 100 or 200 mg/kg, and the remaining group was given dimethyl sulfoxide which was used as a solvent for both drugs. 6 h after the second injection, the mice were killed and bonemarrow preparations were made. Hycanthone induced a significant increase in the frequency of micronuclei in the polychromatic erythrocytes and suppressed the P/N ratio significantly. However, there was no dose-response relationship. Maleic hydrazide, on the other hand, failed to influence the incidence of micronuclei or the ratio of poly- to normo-chromatic erythrocytes.
MeSH terms
Animals; Bone Marrow; Cell Nucleus; Dose-Response Relationship, Drug; Erythrocytes; Genetic Techniques; Hycanthone; Male; Maleic Hydrazide; Mice; Mutagens; Pyridazines; Thioxanthenes
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