Effects of beta-adrenoceptor agonists on airway smooth muscle and on slow-contracting skeletal muscle: in vitro and in vivo results compared.
Acta Pharmacol Toxicol (Copenh), 1979/4;44(4):272-6.
Olsson OA, Swanberg E, Svedinger I, Waldeck B
PMID: 34976
Abstract
Ten beta-adrenoceptor agonists were examined with respect to a) relaxation of pilocarpine-contracted trachea and depression of contractions of the soleus muscle of the guinea-pig in vitro and b) counteraction of histamine-induced bronchospasm and depression of contractions of the soleus muscle of the cat in vivo. There was a close correlation between the results obtained in vitro and results obtained on the corresponding tissues in vivo in spite of the different species used. A close correlation was also observed between effects on airway smooth muscle and on the soleus muscle contractions in vitro as well as in vivo for all compounds examined.
MeSH terms
Adrenergic beta-Agonists; Animals; Bronchi; Cats; Female; Guinea Pigs; Histamine; Male; Muscle Contraction; Muscle, Smooth; Pilocarpine; Species Specificity; Trachea
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