[Long-term study with the novel cardiac glycoside meproscillarin (author's transl)].
Arzneimittelforschung, 1978;28(3a):570-3.
PMID: 348206
Abstract
In a multicentre open therapeutic study 64 physicians provided 650 questionnaires of patients who had been treated with the new cardiac glycoside 14-Hydroxy-3beta-[(4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift) for more than 3 months; 647 questionnaires had been filled in completely and could be evaluated. The major part of all patients suffering from heart failure of the severity degrees I--III required 2 tablets of 0.25 mg, a smaller part 3 tablets to achieve complete recompensation and/or maintenance of compensation, which was possible in 79% of all cases. The rate of side effects corresponded to that of other cardiac glycosides.
MeSH terms
Adult; Aged; Cardiac Glycosides; Clinical Trials as Topic; Female; Heart Diseases; Humans; Male; Middle Aged; Time Factors
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