Stimulation of human platelets by carrageenans.
J Pharm Pharmacol, 1979/3;31(3):148-52.
McMillan RM, MacIntyre DE, Gordon JL
PMID: 34687
Impact factor: 4.81
Abstract
The rank order of four carrageenans tested as inducers of human platelet aggregation was the same (iota greater than lambda greater than gelcarin greater than kappa) as their relative inflammatory potencies in vivo. All four carrageenans caused some precipitation of plasma proteins, and induced aggregation in platelet-rich plasma or washed platelet suspensions. The second phase of aggregation was citrate-dependent and associated with secretion of 5-hydroxytryptamine and lysosomal enzymes. Platelets could provide a useful model for investigating the actions of carrageenans on cell membranes.
MeSH terms
Blood Platelets; Blood Proteins; Carrageenan; Humans; In Vitro Techniques; Platelet Aggregation; Time Factors
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