Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives.
Proc Natl Acad Sci U S A, 1978/2;75(2):928-30.
Umezawa K, Shirai A, Matsushima T, Sugimura T
PMID: 345280
Impact factor: 12.779
Abstract
Norharman enhanced the known mutagenicity of 2-acetylaminofluorene derivatives in the Salmonella test system. The mutagenicities of 2-acetylaminofluorene, 2-aminofluorene, and N-hydroxy-2-acetylaminofluorene were enhanced by norharman only when rat liver microsomal enzymes were added, whereas the mutagenicity of N-acetoxy-2-acetylaminofluorene was increased in the absence of microsomal enzymes. Harman also increased mutagenesis, althouth less so than norharman.
MeSH terms
2-Acetylaminofluorene; Alkaloids; Carbolines; Drug Synergism; Fluorenes; Harmine; Microsomes, Liver; Mutagens; Salmonella typhimurium
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