Targeted and untargeted analysis of triazole fungicides and their metabolites in fruits and vegetables by UHPLC-orbitrap-MS2.
Food Chem, 2022/1/30;368:130860.
Hergueta-Castillo ME[1], López-Rodríguez E[1], López-Ruiz R[1], Romero-González R[1], Garrido Frenich A[2]
Affiliations
PMID: 34425340DOI: 10.1016/j.foodchem.2021.130860
Impact factor: 9.231
Abstract
Two extraction methods based on solid liquid extraction and Quick, Easy, Cheap, Effective, Rugged and Safe procedure were developed for the determination of 21 triazole compounds and 5 metabolites, including triazole derivative metabolites as 1,2,4-triazole and 1,2,4-triazol 1-yl-acetic, in courgette, orange, grape and strawberry. The analysis was performed in 10.5 min, using ultra-high performance liquid chromatography coupled to Q-Orbitrap mass analyser. The proposed method was validated according to SANTE 12682/2019. Limits of quantification were ≤10 µg kg-1 for all the compounds, except for 1,2,4-triazol, 1,2,4-triazol 1-yl-acetic, difenoconazole-alcohol and prothioconazole that were 50 µg kg-1. Finally, the method was successfully applied to the analysis of 30 samples. More than 30% of these samples contained residues of triazole compounds. The fungicide most frequently found was myclobutanil. Furthermore, a suspect screening analysis was carried out to search pesticides present in the samples, detecting some of them at concentrations higher than Maximum Residue Limits.
Keywords: Fruits; QuEChERS; SLE; Triazole fungicides; UHPLC-Q-Orbitrap-MS(2); Vegetables
MeSH terms
Chromatography, High Pressure Liquid; Fruit; Fungicides, Industrial; Pesticide Residues; Tandem Mass Spectrometry; Triazoles; Vegetables
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