Differential effect of D-glucose anomers on proinsulin biosynthesis by the pancreatic islets.
Can J Physiol Pharmacol, 1977/12;55(6):1397-400.
PMID: 340017
Impact factor: 2.245
Abstract
Pancreatic islets of Langerhans of the rat were used to study effects of D-glucose anomers on the incorporation of [3H]leucine into proinsulin and other islet proteins. At low (1 mg/ml), but not at high (2 mg/ml) glucose concentration, the alpha-anomer stimulated more proinsulin biosynthesis than the beta-anomer. This observation adds to the growing list of islet functions showing anomeric preference for alpha-D-glucose.
MeSH terms
Animals; Glucose; In Vitro Techniques; Islets of Langerhans; Isomerism; Male; Proinsulin; Rats; Structure-Activity Relationship
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