Formaldehyde induced anti-N: a possible cause of renal graft failure.
J Clin Pathol, 1977/10;30(10):956-9.
Gorst DW, Riches RA, Renton PH
PMID: 338635
Impact factor: 4.463
Abstract
Treatment of human red cells with low concentrations of formaldehyde induces an antigenic change which makes them react very strongly with the anti-N sera found in certain patients treated by haemodialysis. This supports the idea that formaldehyde sterilisation of reusable home dialysers leads to the development of anti-N in these patients' sera. The clinical problems produced by this antibody are discussed together with ways of overcoming them.
MeSH terms
Antibody Formation; Erythrocytes; Formaldehyde; Graft Rejection; Humans; Kidney Transplantation; MNSs Blood-Group System; Renal Dialysis; Sterilization
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