[Tetrahydropyridoazepine and tetrahydropyridoazepinone derivatives. I. Derivatives of 2,3,4,5-tetrahydro-1H-pyrido[3,2b]azepine and of the corresponding lactam].
Farmaco Sci, 1978/12;33(12):984-91.
Jössang Yanagida A, Gansser C, Miesch F
PMID: 33830
Abstract
Preparation of N-derivatives of 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepine and, in one case, of 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepine-2-one was achieved by introducing the substituents COCl, CONH2, CO2(CH2)3N(CH3)2, COCH2Br and (CH2)3N(CH3)2. The pharmacological results indicate some effect on the ANS.
MeSH terms
Adrenergic alpha-Antagonists; Animals; Antineoplastic Agents; Azepines; Blood Pressure; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lethal Dose 50; Leukemia L1210; Methods; Mice; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Rats
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