[Effect of violamycin BI on the process of excision repair in Escherichia coli K 12 following UV irradiation].
Z Allg Mikrobiol, 1977;17(6):459-64.
PMID: 337690
Abstract
The influence of violamycin B I on the process of excision repair of DNA-damages after UV-irradiation has been studied by observing the capacity to rejoin single-strand breaks introduced in the DNA at the beginning of the repair process. The number of single-strand breaks remaining unrepaired in the DNA was higher in presence of violamycin B I. Sedimentation analysis of the DNA of unirradiated cells showed in presence of violamycin B I only a small change in the molecular weight. As a possible reason for the lower capacity of the cells to accomplish repair steps following incision in presence of violamycin B I an inhibition of the function of repair enzymes by interaction of the antibiotic with the DNA-template is discussed.
MeSH terms
Aminoglycosides; Anti-Bacterial Agents; DNA Repair; DNA, Bacterial; Escherichia coli; Molecular Weight; Ultraviolet Rays
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