Leukocytic response to inhaled bacteria.
Am Rev Respir Dis, 1977/10;116(4):679-84.
Pierce AK, Reynolds RC, Harris GD
PMID: 335934
Abstract
Using histologic techniques, we have quantified the amount of infiltration of bronchi and alveoli by polymorphonuclear leukocytes during the 4 hours after an aerosol inoculation of mice with bacteria. Although the lungs of animals challenged with Staphylococcus aureus differed little from those of animals exposed only to a water aerosol, the lungs of animals exposed to Klebsiella pneumoniae or to Escherichia coli demonstrated significantly greater polymorphonuclear leukocyte infiltrations in bronchi and alveoli 2 and 4 hours afer exposure. These results suggest that the polymorphonuclear leukocyte may contribute to the early defense of the lung against some bacteria.
MeSH terms
Aerosols; Animals; Bronchi; Escherichia coli; Inflammation; Klebsiella pneumoniae; Lung; Mice; Neutrophils; Phagocytosis; Pulmonary Alveoli; Staphylococcus aureus; Time Factors
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