Lack of release of prostaglandins from isolated perfused lungs during pulmonary hypertension and oedema.
Br J Pharmacol, 1979/2;65(2):197-204.
PMID: 32945
Impact factor: 9.473
Abstract
1 The effects on pulmonary prostaglandin synthesis of pulmonary hypertension and oedema have been studied. 2 Seventeen isolated lungs of rabbit, cat and guinea-pig were perfused with plasma, whole blood or Krebs Ringer solution in a recirculating system. 3 The venous effluent from the lungs superfused (10 ml/min) a series of smooth muscle tissues sensitive to prostaglandins and thromboxane A2; these were: rat stomach strip, rat colon, chick rectum and rabbit aorta. 4 Left atrial pressure was increased by between 10 and 30 mmHg for periods of 3 to 59 minutes. Gross alveolar oedema eventually developed in all experiments. 5 Neither pulmonary hypertension nor subsequent oedema caused release of prostaglandins into the venous effluent.
MeSH terms
Animals; Blood Pressure; Cats; Guinea Pigs; Hydrogen-Ion Concentration; Hypertension, Pulmonary; In Vitro Techniques; Lung; Prostaglandins; Pulmonary Edema; Rabbits; Respiration; Time Factors
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